MASP2 levels are elevated in thrombotic microangiopathies: association with microvascular endothelial cell injury and suppression by anti-MASP2 antibody narsoplimab.

However, sC5b‐9 levels in the subset of patients with TMAs post‐alloHSCT did not reach statistical significance, either when compared to levels recorded in individuals post‐alloHSCT who did not develop a TMA ( n = 80; P = 0·40) or versus a healthy control group for which fewer individuals were available ( n = 6; P = 0·26; Table 2 ).

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At the time of development of a persistent HSCT‐TMA, MASP2 levels remained elevated over healthy controls, but with a trend towards lower levels, and a highly significant lower variance, than in those individuals not developing a TMA post‐alloHSCT The clinical relevance of these findings is strengthened by studies of the role of the LP in other thrombotic states.

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