Thrombin alters the synthesis and processing of CYR61/CCN1 in human corneal stromal fibroblasts and myofibroblasts through multiple distinct mechanisms.

Mol Vis · 2020 · PMC7406864 · PMID 32818017

Europe PMC

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did not reach statistical significanceno p-value reported

However, treatment with the PAR-1 antagonist SCH 79797 significantly inhibited Cyr61 synthesis in fibroblasts but not in myofibroblasts, where the observed decrease did not reach statistical significance.

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