Risk factors for MEK-associated retinopathy in patients with advanced melanoma treated with combination BRAF and MEK inhibitor therapy.

While our study found no significant correlation between sex and MEKAR, the data showed a trend towards females experiencing more severe grades of retinopathy, which is not consistent with the sex risk factor for CSCR of being male. 16 Hypertension, systemic vascular disease, and corticosteroid use were not identified as significant risk factors for MEKAR, likely due to the underlying differences in disease pathophysiology as well as the exclusion criteria of the primary study.

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