Slc38a1 Conveys Astroglia-Derived Glutamine into GABAergic Interneurons for Neurotransmitter GABA Synthesis.

Measurements at the pyramidal cell layer-to-oriens layer interface (which has the highest density of GABAergic terminals, Figure 3 A) showed a highly significant increase of GABA signal on glutamine supplementation in Slc38a1 +/+ mice, but not in Slc38a1 −/− mice.

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Without glutamine, there was a tendency towards lower GABA signal in Slc38a1 −/− mice compared to Slc38a1 +/+ mice, but this did not reach statistical significance.

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