An increasing trend for risk, of 31% and 66% for every 5-year period when period of diagnosis was considered as a continuous variable, was also detected specifically for tonsillar and base of tongue cancers, respectively (supplementary Tables 6 and 7 ).
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Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe.
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Of note, calendar period and age did not show a clear trend in the multivariable analysis for all OPC sites and for tonsil.