Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC.

Mol Ther Nucleic Acids · 2020 · PMC7415771 · PMID 32771924

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a clear trendno p-value reported

By comparison, metabolites related to sequential loss of GalNAcs from sense strand show a clear trend, where −2 GalNAc accumulation follows −1 GalNAc by a lag and −3 GalNAc follows −2 GalNAc by a similar time lag.

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