Hypoxia dynamics on FMISO-PET in combination with PD-1/PD-L1 expression has an impact on the clinical outcome of patients with Head-and-neck Squamous Cell Carcinoma undergoing Chemoradiation.

Theranostics · 2020 · PMC7415814 · PMID 32802199

Europe PMC DOI

hedged sentences

0.0520

closest p · 1.0× alpha

0.0520

boldest claim

The sentences

borderline significancep = 0.052so close (0.05 < p ≤ 0.1)

In the multivariate analysis, only the combination of absent early hypoxia response and positive TPS remained a significant prognosticator for LRC (HR = 3.374, 95% CI 1.192 - 9.548, p = 0.022) and, with borderline significance, for PFS (HR = 2.752, 95% CI 0.992 - 7.631, p = 0.052).

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showed a trendp = 0.052so close (0.05 < p ≤ 0.1)

TPS) alone did not influence LRC or PFS, patients with absent early hypoxia response and positive TPS exhibited significantly reduced LRC (HR = 3.374, 95% CI 1.192 - 9.548, p = 0.022) and showed a trend towards impaired PFS (HR = 2.752, 95% CI 0.992 - 7.631, p = 0.052).

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