Plasma big endothelin-1 is an effective predictor for ventricular arrythmias and end-stage events in primary prevention implantable cardioverter- defibrillator indication patients.

Compared to tertile 2, the risk for patients in tertile 3 was higher, but it did not reach statistical significance, which may be related to the high mortality rate of tertile 3 and the small number of patients included in this study.

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