SPG7 mutations in amyotrophic lateral sclerosis: a genetic link to hereditary spastic paraplegia.

However, the difference in disease duration (comparing 9 SPG7 variant carriers versus 205 non-carriers; P = 0.20, T test) and in survival (comparing 6 SPG7 variant carriers versus 88 non-carriers; P = 0.749, log-rank test) did not reach statistical significance (Supplementary Table 3).

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In line with these findings, there was a slight trend toward longer disease duration in SPG7 versus non- SPG7 variant carriers (Supplementary Table 3), suggesting that ALS patients with rare SPG7 variants may have a somewhat better prognosis than non-carriers.

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