Investigating the GWAS-Implicated Loci for Rheumatoid Arthritis in the Pakistani Population.

Eight other SNPs showed marginal significance: C5orf30 /rs26232 ( p = 3.73 E − 02), CCL21 /rs951005 ( p = 2.75 E − 02), GATA3 /rs2275806 ( p = 4.02 E − 02), VPS37C /rs595158 ( p = 3.10 E − 02), HLA-DRB1 /rs660895 ( p = 4.02 E − 02), EOMES /rs3806624 ( p = 3.54 E − 02), SPRED2 /rs934734 ( p = 4.24 E − 02), and RUNX1 /rs9979383 ( p = 3.48 E − 02).

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A weakness of our study is the availability of relatively small-sized sample, which may have prevented 36 SNPs from achieving the significance threshold, although they showed a trend for the same directional effects as the reported ones.

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