Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline.

Acta Neuropathol · 2020 · PMC7423866 · PMID 32720099

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

approaching significanceP = 0.060so close (0.05 < p ≤ 0.1)

Plasma p-tau181 was only significantly increased from timepoint 1 to timepoint 3 in the AD pathology group ( P = 0.0006), although an increase approaching significance was also observed in the mixed AD pathology group ( P = 0.060, Fig. 5 ).

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