11β-Hydroxysteroid dehydrogenase type 1 inhibition in idiopathic intracranial hypertension: a double-blind randomized controlled trial.

There was a significant reduction in ICP in the AZD4017 and not the placebo group over the treatment duration (exploratory within-group analysis) and reduction in ICP significantly correlated with reduction in serum cortisol:cortisone ratio; however, the primary analysis evaluating the difference between groups at 12 weeks did not reach statistical significance.

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