Early Inspiratory Effort Assessment by Esophageal Manometry Predicts Noninvasive Ventilation Outcome in <i>De Novo</i> Respiratory Failure. A Pilot Study.

Among the other predictors tested, V t e > 9.5 ml/kg of PBW and HACOR > 5 after 2 hours of NIV were significantly associated with NIV failure at 24 hours (OR, 7.9; 95% CI, 1.5–72; P = 0.02 and OR, 6.3; 95% CI, 0.9–49; P = 0.046, respectively), whereas RR > 30 bpm, Pa O 2 /F i O 2 ratio < 150 mm Hg, and V t e/ΔP l ratio < 0.33 ml/kg/cm H 2 O, although strongly associated, did not reach statistical significance ( Table 3 ).

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