Epidemiologic studies show that there is a clear trend of significantly decreasing risk of EOC with increasing numbers of pregnancies and deliveries, extended duration of oral contraceptive use, and extended duration of breastfeeding, all of which are associated with lower levels of and reduced exposure to FSH 6 .
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Follicle-stimulating hormone promotes the proliferation of epithelial ovarian cancer cells by activating sphingosine kinase.
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