44 A single study involving 56 patients showed a trend toward increased dilated cardiomyopathy among extensive metabolizers after adjusting for age and sex. 45 Patterns of methamphetamine use may play an important role in the development of MACM as the pathologic effects of the drug have been shown to be dose dependent and amplified by repetitive use, binge pattern use, and concomitant use of other substances (see Physiologic Effects of Methamphetamines ).
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Clinical Characteristics and Management of Methamphetamine-Associated Cardiomyopathy: State-of-the-Art Review.
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