Long-term effects of latitude, ambient temperature, and ultraviolet radiation on the incidence of multiple sclerosis in two cohorts of US women.

Each IQR increase (3.91°) in cumulative average July temperature was associated with decreased risks of MS, although the multivariable and fully-adjusted models did not reach statistical significance in either cohort, they did in the meta-analysis pooling the HRs (meta-analysis multivariate-adjusted HR: 0.81; 95% CI 0.72, 0.91 and meta-analysis fully adjusted HR: 0.85; 95% CI 0.74, 0.98), Table 3 ).

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