Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α-activated fibroblast-like synoviocytes: an in vitro, coculture model of inflammatory pain.

By contrast, knee neurons in neuron/TNF-FLS coculture showed a trend for larger magnitude of capsaicin esponses (27.7 ± 9.3 pA/pF, n = 8/21), and those cultured with TNF-FLS media had a capsaicin response of 65.8 ± 25.7 pA/pF (n = 7/20), which was significantly larger in magnitude than neuronal monoculture ( P = 0.02) and neuron/control FLS coculture ( P = 0.02) (ANOVA followed by Tukey post hoc comparison, Figs. 4 Ai and ii).

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