Gene editing and elimination of latent herpes simplex virus in vivo.

While reduction of viral load in TG did not reach statistical significance as previously seen with dual-meganuclease therapy (Fig. 1b ), a ~65% reduction in mean HSV load in SCG was detected (mean 6 × 10 3 HSV genomes/10 6 ganglionic cells in treated mice, compared with a mean of 3.7 × 10 4 HSV genomes/10 6 ganglionic cells in control animals, p = 0.017) (Fig. 2b ).

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