A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment.

In this more complex model, the main effect of APOE showed a trend (F(1,68) = 3.68, p = .059, η p 2 = .051), with higher scores for ε4 carriers compared to non-carriers, and there was also a trend for an interaction between APOE and age, with ε4 carriers scoring higher than non-carriers at younger ages and lower at older ages (F(1,68) = 3.60, p = .062, η p 2 = .050). 3.3 Discussion APOE genotype was deemed a possible predictor of individual differences since in adulthood in DS, it increases the risk of AD by a hazard ratio of 1.8 and there is evidence that the genotype also influences early brain development ( Dean et al., 2014 ; Prasher et al., 2008 ).

also in 53,322 other papers

However, this was only present as a statistical trend, which would be weakened further by any Bonferroni corrections for multiple comparisons / analyses.

also in 2,798 other papers