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Meta-analysis of the efficacy and safety of non-vitamin K antagonist oral anticoagulants with warfarin in Latin American patients with atrial fibrillation.

Medicine (Baltimore) · 2020 · PMC7440306 · PMID 32358343

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a strong trendno p-value reported
In addition, standard-dose NOACs had a strong trend toward a decrease in major bleeding, whereas low-dose NOACs significantly reduced this bleeding risk. 3.4.

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