Addiction to protein kinase Cɩ due to PRKCI gene amplification can be exploited for an aptamer-based targeted therapy in ovarian cancer.

Signal Transduct Target Ther · 2020 · PMC7441162 · PMID 32820156

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showed a trendno p-value reported

Further MTT assays showed a trend that growth of PRKCI -amplified cell lines is greatly inhibited by knockdown of PKCι whereas silencing PKCι displayed little effect in growth of non- PRKCI -amplified lines (Fig. 3d ).

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