Lower peripheral helper T cell levels in the synovium are associated with a better response to anti-TNF therapy in rheumatoid arthritis.

We found a highly significant correlation between the microarray and the RT-PCR gene expression quantification (Pearson correlation coefficients r = 0.89, P = 3.6e−8 and r = 0.65 P = 0.0009 for CTLA4 and TIMELESS , respectively) (Supplementary Figure 5 ).

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Genes with a nominally significant differential expression and a fold change > 1.2 were selected as input for this analysis; Bonferroni multiple test correction was applied to determine significant GO terms.

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