Impaired proteasome activity and neurodegeneration with brain iron accumulation in FBXO7 defect.

Ann Clin Transl Neurol · 2020 · PMC7448169 · PMID 32767480

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showed a trendno p-value reported

10 We have demonstrated that the UPS activity was reduced in FBXO7‐PPS patient’s fibroblasts, and as a consequence, the poly‐UB proteins showed a trend to accumulate.

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