Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity.

Comparing human islet RNA-seq data with INS-1E cell microarray data following palmitate exposure revealed highly significant overlap, most prominent for upregulated genes (Fig. 1 a, bottom left corner) but also for downregulated genes (upper right corner).

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qPCR showed a trend for BACH1 induction in INS-1E cells and significant upregulation of BACH1 in human islets exposed to palmitate (Supplementary Fig. 4 A-B).

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