We observed nominally significant directionally consistent effects for advanced AMD (OR adv = 1.05, 95% confidence interval, CI = [1.01,1.09] and 1.03 [1.00,1.07], P adv = 0.02 and 0.05, respectively) that were slightly smaller compared to early AMD effects (OR early = 1.10 [1.06,1.14] and 1.05 [1.02,1.08], P early = 4.7 × 10 − 8 and 6.8 × 10 − 4 ).
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Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease.
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