Fate mapping via CCR2-CreER mice reveals monocyte-to-microglia transition in development and neonatal stroke.

The TRAP analysis also showed a trend of gradual reduction in M1-like markers [ TNF α, IL1 α, and interleukin-1 β ( IL-1 β)] and an inverse increase in M2-like macrophage markers by monocyte derivatives from 48 hours to 14 days in poststroke brain ( Fig. 6K , n = 3 for each time point) ( 37 ).

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