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Characterization of Retinal Microvascular Complications and the Effects of Endoplasmic Reticulum Stress in Mouse Models of Diabetic Atherosclerosis.

Invest Ophthalmol Vis Sci · 2020 · PMC7452854 · PMID 32852545

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Although there was a trend toward decreased microvessel density in the central regions of GlcN-supplemented ApoE −/− , STZ-injected ApoE −/− , and ApoE −/− :Ins2 +/Akita mice compared to controls, this did not reach statistical significance. 4PBA treatment rescued the decline in microvessel density in the mid- and peripheral regions of STZ-injected ApoE −/− and ApoE −/− :Ins2 +/Akita mice ( Figs. 1 B, 1 C, 1 D).

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