Comparative Population Pharmacokinetics of Darunavir in SARS-CoV-2 Patients vs. HIV Patients: The Role of Interleukin-6.

Clin Pharmacokinet · 2020 · PMC7453069 · PMID 32856282

Europe PMC DOI

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0.0700

closest p · 1.4× alpha

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boldest claim

The sentences

showed a trendp = 0.07so close (0.05 < p ≤ 0.1)

The Prominent Role of Interleukin-6 on Darunavir Pharmacokinetics in SARS-CoV-2 Patients IL-6 showed a trend toward a significant relationship with the three-stage classification system of SARS-CoV-2 disease severity (Spearman ρ = 0.34, p = 0.07) and was the only clinical variable highly significantly associated with darunavir CL/F at multivariate regression analysis ( p < 0.001) [Table 3 ].

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almost significantlyno p-value reported

Most of our patients had severe SARS-CoV-2 disease (overall, 63.3% were classified as stage IIb and III) [ 3 ], and the severity of SARS-CoV-2 disease was found to be almost significantly correlated with IL-6 levels.

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