Effect of a Daily Text Messaging and Directly Supervised Therapy Intervention on Oral Mercaptopurine Adherence in Children With Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.

After adjusting for baseline adherence, time in the study, and paternal education, the difference in proportion of patients with mercaptopurine adherence rate 95% or higher in the intervention and education groups did not reach statistical significance at the prespecified P value of 0.017 (entire cohort, OR, 1.33 [95% CI, 1.0-2.0]; P = .08; patients <12 years old, OR, 1.53 [95% CI, 1.0-2.2]; P = .04; patients ≥12 years old, OR, 0.8 [95% CI, 0.6-1.8]; P = .80).

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