Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer.

The 5 years DFS rates were 100% in the group of POLE EDMs, 82.0% in the group of MSI-H and 63.0% in the group of MSS, with a significant p value of 0.013 among the three groups ( figure 3E ); the 5 years OS rates were 100% in the group of POLE EDMs, 90.3% in the group of MSI-H and 80.8% in the group of MSS, with a clear trend and marginal significant p value ( figure 3F ).

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