C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodeling.

Consistent with previous work ( 2 , 12 ), we observed a correlation between C5aR1 expression (decreased after C5a exposure) and phagocytosis ( Figure 7C ) and an inverse correlation between C5aR1 expression and phagosomal acidification ( Figure 7D ), though the latter correlation did not reach statistical significance.

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