Heart rate fragmentation gives novel insights into non-autonomic mechanisms governing beat-to-beat control of the heart's rhythm.

In the univariate model, PIP (chosen to represent all other heart rate fragmentation measures) demonstrated a highly significant ability to predict mortality (p = 1.71E-16).

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In the univariate models (2nd thru 4th columns), heart rate, standard deviation of heart rate, and COSEn all failed to reach statistical significance affirming our previous assertion that COSEn has its main value in atrial fibrillation detection from short segments 10 , 16 rather than as a predictor of mortality.

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