Sex-specific effects of the histone variant H2A.Z on fear memory, stress-enhanced fear learning and hypersensitivity to pain.

Sci Rep · 2020 · PMC7458907 · PMID 32868857

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0.0680

closest p · 1.4× alpha

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approaching significancep = 0.068so close (0.05 < p ≤ 0.1)

To confirm H2A.Z depletion from chromatin, we conducted ChIP in area CA1 from H2A.Z cKO and control female mice and showed an approximately 25% reduction in H2A.Z binding at Fos (t 10 = 3.23, p = 0.009), Arc (t 10 = 2.53, p = 0.03), Gadd45b (t 10 = 2.29, p = 0.05), and Fkbp5 (t 9 = 2.47, p = 0.04) genes, with reduced H2A.Z binding at Th approaching significance (t 10 = 2.05, p = 0.068) (Fig. 2 d).

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