Multifactorial Design of a Supramolecular Peptide Anti-IL-17 Vaccine Toward the Treatment of Psoriasis.

Strikingly, despite elevated IgG1 and total IgG titers compared to unadjuvanted controls, CpG-adjuvanted nanofibers exhibited the highest average epidermal thickness among all groups tested ( Figures 6C,G ), suggesting an exacerbation of psoriatic symptoms compared to unimmunized or immunized groups, although comparisons to unimmunized mice did not reach statistical significance.

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