A MALT1 inhibitor suppresses human myeloid DC, effector T-cell and B-cell responses and retains Th1/regulatory T-cell homeostasis.

We demonstrated a modest effect on the inhibition of the IKK-dependent phosphorylation of Iα with the allosteric MALT1 inhibitors, mepazine and Compound 2 in human CD4 T-cells, while the active site inhibitor did not reach statistical significance ( Fig 2C and 2D ).

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