The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities.

Cancers (Basel) · 2020 · PMC7465136 · PMID 32751160

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a clear trendno p-value reported

Our analysis of the TCGA RNA-Seq data revealed a clear trend towards DYRK1A downregulation in tumor tissues, with a significant downregulation of DYRK1A in 11 out of the 15 tumor types considered ( Table S1 ): colon (COADREAD), esophagus (ESCA), HNSCC, kidney (KIRP and KIRC), liver (LIHC), lung (LUSC and LUAD), stomach (STAD), thyroid (THCA) and uterus (UCEC).

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