BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain-Implications for Neurodegeneration.

Finally, the analysis of AMPK active form per total protein levels ratio (p-AMPK Thr172 /AMPK) as an index of AMPK activation process, reveals a strong increase at 2 months (+1188%, p < 0.0001) that is nearly significant at 6 months (+275%, p = 0.06) but is not significantly different at 11 months in BVR-A −/− with respect to WT mice ( Figure 5 D.1).

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