Mechanisms underlying genome instability mediated by formation of foldback inversions in <i>Saccharomyces cerevisiae</i>.

Similarly, deletion of YEN1 , which encodes a 5' flap/Holliday junction endonuclease ( Ip et al., 2008 ), did not cause an increase in the overall uGCR rate but did cause a fivefold increase in the foldback inversion GCR rate compared to the wild-type strain that was of borderline significance (p=0.06, Mann Whitney U-test; Figure 8A ; Supplementary file 1 ), all of which were mediated by large-loop ssDNA hairpins (4 of 11 GCRs compared to 1 of 27 GCRs for the wild-type strain; p=0.02 Fisher’s exact test) ( Figure 8B ), suggesting that YEN1 may define a large-loop ssDNA hairpin suppression pathway.

also in 2,624 other papers

Similarly, the sae2Δ mus81Δ double mutant had a small increase in the uGCR rate and a decrease in the foldback inversion GCR rate compared to the sae2Δ single mutant that did not reach statistical significance based on 95% confidence intervals ( Supplementary file 1 ).

also in 111,027 other papers