Potential of platinum-resensitization by Wnt signaling modulators as treatment approach for epithelial ovarian cancer.

Except for SB216763 and XAV939 in A2780cis, these findings were highly significant ( p < 0.01 or p < 0.001) at the selected concentrations of 100 μM SB216763, 50 μM XAV939 and 50 nM triptolide (Fig. 3 b).

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A similar trend was noted for OS, although this difference did not reach statistical significance (50.4 ± 13.2 to 27.6 ± 3.6 months [ p = 0.058]) (Fig. 7 ).

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Interestingly, it is the only Wnt marker tested with a clear correlation to PFS or OS: in our study an elevated expression of snail/ slug in the serous subtype is significantly associated with longer PFS and shows a positive trend for OS.

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