Human urine samples taken over the course of the menstrual cycle show lowest levels of IL-1RA during menses; and experiments with LPS-stimulated monocytes show increased secretion of IL-1β following ovulation, along with an upward trend of IL-1RA that did not reach statistical significance [ 40 , 41 ].
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Serum IL-1RA levels increase from follicular to luteal phase of the ovarian cycle: A pilot study on human female immune responses.
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