Real-World Effectiveness of Obeticholic Acid in Patients with Primary Biliary Cholangitis.

Patients with LSM ≥16.9 kPa experienced a nominally significant reduction in mean ALP from 220 U/L (95% CI, 170‐285) at initiation to 211 U/L (95% CI, 157‐283) at 12 months ( P < 0.05) compared to patients with an LSM <16.9 kPa (n = 45), who demonstrated a 67‐U/L reduction in mean ALP from 288 U/L (95% CI, 249‐332) to 221 U/L (95% CI, 191‐256) over 12 months ( P < 0.01), although ALP at initiation was lower among those with advanced disease (Supporting Table S2 ).

also in 7,732 other papers