Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.

While only variants with P < 5 × 10 −8 were considered significant, to also identify suggestive variants for supplementary results, in each clump, index SNPs had a suggestive association based on P < 1×10 −6 , and SNPs were added if they were marginally significant with P < 0.05, were within 500 kb of the index SNP, and had r 2 > 0.1 with the index SNP.

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We also identified several cancer pairs for which the genetic correlations were nominally significant.

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