Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain.

Nat Commun · 2020 · PMC7474063 · PMID 32887883

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0.0670

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0.0670

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did not reach statistical significanceP = 0.067so close (0.05 < p ≤ 0.1)

While numerous risk genes of other neurovascular and neurodegenerative diseases also overlapped with aged EC DEGs, they did not reach statistical significance for overrepresentation in any EC subtypes (Fig. 3a , e.g. number of overlapped genes for stroke genes and capEC DEGs = 4; P = 0.067).

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