Thereby, IFNG , GZMB , and IL21R were significantly upregulated in CD25+CD4+ TILs, while expression of several cytokines ( IL21 , IL6 , IL1B , and IL5 ) was enhanced but did not reach statistical significance (as determined by p<0.05 and Log2FC>0.3, figure 4A ).
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FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells.
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