Dendritic cell IL-10 knockout mice treated with cisplatin showed a trend towards increased expression of Il6 , though not statistically significant, but similar expression of tgfβ , and tnfα in comparison with Il10 flox/flox mice treated with cisplatin ( Fig 4B ) .
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IL-10 from dendritic cells but not from T regulatory cells protects against cisplatin-induced nephrotoxicity.
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