DNA methylation study of Huntington's disease and motor progression in patients and in animal models.

Analyzing the same brain regions from another group of mice using our custom array platform revealed another highly significant CpG to be hypomethylated in the Q175 group (probe cg12389415 on the custom array, mouse chr5:34795955) also within the Htt locus (meta-analysis p = 3.2 × 10 −22 ; Supplementary Fig. 25 ).

also in 132,142 other papers

The considered measures of epigenetic AgeAccel exhibit nominally significant positive correlations with motor progression (e.g., r = 0.08, meta-analysis p = 0.016 for the pan-tissue clock; Supplementary Table 8 and Supplementary Fig. 7 ).

also in 7,732 other papers