Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis.

In the systematic review and meta-analysis of studies addressing host genetic factors implicated in five common respiratory tract infectious diseases—i.e tuberculosis, influenza, respiratory syncytial virus (RSV) and SARS-CoV—published in 2015 [ 14 ], Patarčić and co-workers reported IL4 as the single result that was significant in pooled analyses, and marginally significant in disease-specific meta-analyses.

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Many nominally significant signals of association listed in tables would not survive to rigorous corrections for multiple testing (see Table 3 ).

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