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Methadone and a Clinical Pathway in Adolescent Idiopathic Scoliosis Surgery: A Historically Controlled Study.

Global Spine J · 2020 · PMC7485079 · PMID 32905725

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an overall trendno p-value reported
There was an overall trend toward decreased pain scores and opioid use throughout all time periods compared with the historical control.

also in 4,871 other papers

showed a trendno p-value reported
We also showed a trend toward improved pain control with the >0.25 mg/kg dose at the expense of prolonged emergence.

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.