Population Analysis of Anidulafungin in Infants to Older Adults With Confirmed or Suspected Invasive Candidiasis.

23 , 24 Our results also showed a trend toward a lower median exposure in patients weighing < 30 kg; however, a target AUC for efficacy was not determined in a previous study and lower AUC (< 40 mg*hour/L) did not impact on treatment success. 22 Exposure‐response efficacy analyses showed no relationship between systemic anidulafungin exposure measures and global response or all‐cause mortality at end of i.v. treatment, EOT, or EOS.

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Graphical quantile analysis of systemic anidulafungin exposure parameter AUC 0–24,ss as a potential predictor for hepatic and GI AEs revealed a slight trend toward an increased incidence of all‐cause hepatic AEs with higher estimated systemic exposure in the pooled data from all three clinical studies, but not in study 1 alone ( Figure 4 ).

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