α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo.

In contrast, a robust and highly significant increase was found in the dopaminergic neurons of α-Syn zebrafish under identical conditions (α-Syn post-MPP + 1.73 ± 0.09; p < 10 −15 vs . baseline, 2-way ANOVA with Tukey multiple comparisons test; Fig. 5 E).

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A similar, but more modest, difference was apparent in non-dopaminergic neurons ( Fig. 10 E).

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